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Furthermore, the model confirmed the potent antioxidant capacity of DEC, as evidenced by reduced ROS levels and upregulated Nrf2 expression, suggesting effective dermal penetration and activation of endogenous protective mechanisms

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The researchers demonstrated that theanine dose-dependently decreased histamine release and actively repressed the secretion of pro-inflammatory cytokines like TNF- and IL-1 by suppressing the NF-B pathway